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1.
The omnipotent state of mind: Psychoanalytic perspectives ; : 220-229, 2022.
Article Dans Anglais | APA PsycInfo | ID: covidwho-20245423

Résumé

This chapter describes a model of 'perverted containing' to explain escalating destructive social processes rooted in phantasies of omnipotence and nourished by unconscious fears of annihilation, using the example of Donald Trump-a prime example of a destructive narcissistic populist who offers omnipotence as salvation. It combines Rosenfeld's theory of destructive narcissism and Bion's theory of the container/contained to describe the powerful dynamic existing between Trump and his voters in which the omnipotent appeal of the demagogue held his followers in thrall. Trump offers his supporters omnipotence as perverted containing. He embodies omnipotence as a person;therefore, he appears convincing, so people can easily believe in him-especially those who, on an early level of intensive anxieties, feelings of persecution, and longing for symbiosis, prefer to attach themselves to one person. Thus, he accommodates their desires to identify and bond symbiotically with one person in total consensus-without triangulation, without doubting and space to develop individual perception and judgment. In the 2020 COVID-19 crisis, Trump first used his usual means: distortion and denial of reality, self-praise and directing accusations towards the usual 'enemies'. (PsycInfo Database Record (c) 2023 APA, all rights reserved)

2.
Pharmaceutical Technology Europe ; 33(7):7, 2021.
Article Dans Anglais | ProQuest Central | ID: covidwho-20243758

Résumé

Whilst vaccination is progressing at increasing speed, the virus will not disappear, and patients will need safe and effective treatments to reduce the burden of COVID-19," said Stella Kyriakides, commissioner for Health and Food Safety in a press release (3). Promising candidates The five candidates identified by the EC will be prioritized for review, and it is hoped that three of the therapies will gain authorization by October 2021, permitting the final data demonstrate safety, efficacy, and quality. EC, "Register of Commission Expert Groups and Other Similar Entities: High-Level Group on the Health Emergency Preparedness and Response Authority (HERA) and HERA Incubator (E03770)," ec.europa.eu [Accessed 5 July 2021].

3.
Die Unterrichtspraxis ; 56(1):53-57, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-20243261

Résumé

[...]a large number of lecturers called in sick or declared that they were unable to attend for health and safety reasons. The transition required the following steps: prompt communication with the students about the new modus operandi;staff training on the use of Teams;setting up of Teams exam meetings;evaluation and re-design of the exam content. Another clear benefit of Teams meetings is the centrally stored video recordings for all examinations, which can be used for quality assurance purposes, that is, checking by external examiners, in potential student appeals or academic misconduct investigations. Unstable or poor Internet connection;2. student camera turned off;3. hardware issues with the camera or microphone;4. background noise and echo;5. poor student or examiner information technology (IT) skills.

4.
Revista de Administração Contemporânea ; 27(3):1-15,1A-15A, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2322832

Résumé

Este caso objetiva promover uma reflexao sobre o processo de escrita de casos para ensino e direcionamentos para aplicação do método. Em 2020, João Luiz Marinho, doutorando em Administração na Universidade do Aprendizado (UNIAPRE), foi desafiado pelo professor Fernando a escrever o seu primeiro caso para ensino para aplicação na disciplina de Estratégias Organizacionais, da qual era estagiário em docencia. Porém, muitos questionamentos sobre a construção e aplicação de casos para ensino sondavam os pensamentos de João, uma vez que este nao tinha experiencias anteriores com o método, possuía pouca prática na docencia e a migração das aulas para a modalidade on-line era novidade. Assim, a proposta foi fazer com que os alunos se colocassem no lugar de João, a fim de propiciar um debate sobre a escrita e aplicação de um caso para ensino na modalidade on-line. Sugere-se sua aplicação nos cursos de pos-graduaçâo lato sensu e stricto sensu em Administração, nas disciplinas de Metodologia e Casos para Ensino.Alternate :This case aims to promote a reflection on the teaching case writing process and directions for applying the method. In 2020, João Luiz Marinho, a doctoral candidate in Administration at the University of Learning (UNIAPRE), was challenged by Professor Fernando to write his first teaching case for application in the Organizational Strategies discipline, of which he was an intern in teaching. However, many questions about the construction and application of teaching cases probed João's thoughts, since he had no previous experience with the method, he had little practice in teaching, and the migration of classes to the online mode was very new. Thus, the proposal is to make students put themselves in João's place, in order to provide a debate on the writing and application of a case for online teaching. It is suggested that it be applied in lato sensu and stricto sensu graduate courses in Administration in the disciplines of Methodology and Teaching Cases.

5.
Research and Teaching in a Pandemic World: The Challenges of Establishing Academic Identities During Times of Crisis ; : 361-374, 2023.
Article Dans Anglais | Scopus | ID: covidwho-2322219

Résumé

The COVID-19 pandemic has shaken research in higher education in unexpected ways (OECD, 2021). While it sped up the transition to online and virtual modes of learning within the academe, it also generated significantly higher levels of anxiety and depression among university-based researchers (Chirikov et al., 2020). Higher education institutions adopted widespread changes in teaching loads and research policy at break-neck speed, often to the dismay of early career researchers and doctoral candidates. This chapter investigates the impact of the global health crisis on the research output and strategies of early career researchers and doctoral candidates at universities around the world. It reviews the literature on the impact of the COVID-19 pandemic on research output and strategies. The chapter also incorporates recent findings from the author's research project, which investigates the long-term impact of the pandemic on academic writing strategies and output among doctoral candidates (following on from results previously published in Cahusac de Caux (2021)). © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.

6.
SpringerBriefs in Applied Sciences and Technology ; : 19-26, 2023.
Article Dans Anglais | Scopus | ID: covidwho-2321929

Résumé

Drug repurposing is a cost-effective process to identify therapeutic candidates during a medical crisis or pandemic. The supercomputing platform, EXaSCale smArt pLatform Against paThogEns for CoronaVirus (EXSCALATE4CoV;E4C), was used to identify drug candidates for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. E4C identified raloxifene as having great therapeutic potential, confirmed by in vitro data, which led to the progression of clinical trials to assess its efficacy. Raloxifene met the primary virologic endpoint in the treatment of early mild coronavirus disease 2019 (COVID-19), and although additional clinical trials are needed to confirm these results, there is evidence in support of in silico drug repurposing to provide cost-effective and rapid drug screening to identify treatment options for the pandemic and future pandemics. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

7.
The European Journal of Finance ; 29(2):185-206, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2326310

Résumé

We examine the risk minimization utility of Islamic stock and Sukuk (bond) indices by studying their linkages against traditional global counterparts. We first employ an asymmetric power ARCH-based ADCC model on an extended dataset employed by Kenourgios et al. (2016). Our sample ranges from July 2007 to June 2021 covering the Global Financial Crisis (GFC), the European Sovereign Debt Crisis (ESDC), and the COVID-19 pandemic. Econometric tests suggest strong evidence of coupling in the bulk of Islamic equity indices. A handful of emerging market indices constitute exceptions. Qualitatively similar results emerge from time–frequency analysis via wavelet tools, revealing pervasive coupling in both returns and volatility series. The linkages are scale-dependent in only a few pairs. In contrast, Sukuk indices are uncoupled from their global fixed income counterparts and relevant risky debt portfolios. In sum, the risk-return characteristics of Islamic equities (especially in developed economies) remain coupled to major global benchmarks and therefore are unlikely to appeal as safe haven candidates. The converse applies to Sukuk, which promises potential portfolio diversification benefits and safe haven status in ‘normal' and crisis periods.

8.
SpringerBriefs in Applied Sciences and Technology ; : 9-17, 2023.
Article Dans Anglais | Scopus | ID: covidwho-2325400

Résumé

The COVID-19 pandemic highlighted an urgent need for streamlined drug development processes. Enhanced virtual screening methods could expedite drug discovery via rapid screening of large virtual compound libraries to identify high-priority drug candidates. The EXSCALATE4CoV (EXaSCale smArt pLatform Against paThogEns for CoronaVirus) consortium (E4C) research team developed EXSCALATE (EXaSCale smArt pLatform Against paThogEns), the most complex screening simulation to date, containing a virtual library of >500 billion compounds and a high-throughput docking software, LiGen (Ligand Generator). Additionally, E4C developed a smaller virtual screen of a "safe-in-man” drug library to identify optimal candidates for drug repurposing. To identify compounds targeting SARS-CoV-2, EXSCALATE performed >1 trillion docking simulations to optimize the probability of identifying successful drug candidates. Ligands identified in simulations underwent subsequent in vitro experimentation to determine drug candidates that have anti-SARS-CoV-2 agency and have probable in-human efficacy. While many compound candidates were validated to have anti-SARS-CoV-2 properties, raloxifene had the best outcome and subsequently demonstrated efficacy in a phase 2 clinical trial in patients with early mild-to-moderate COVID-19, providing proof of concept that the in silico approaches used here are a valuable resource during emergencies. After its emergence in 2019, the SARS-CoV-2 coronavirus spread internationally at a rapid pace, leading to the designation of COVID-19 as a pandemic in March 2020. In addition to a devastating impact on public health, COVID-19 has resulted in extensive negative social and economic effects in every corner of the globe. When the pandemic arrived, the medical and scientific communities identified an urgent need to establish more rapid therapeutic and vaccine development processes for COVID-19. However, it was clear that any new measures needed to be implemented in a way that also supported rapid mobilization to fight potential future pandemics. Therapeutic discovery is a complicated and prolonged process, often taking 10–15 years to complete all stages, and typically involves a linear workflow starting with in silico investigations, followed by increasingly complex and correspondingly expensive in vitro, in vivo, and clinical studies. In the context of the pandemic, the importance of the in silico stage increased because of the capacity of exascale computational methods to identify and prioritize small molecule (and biological) agents with the greatest therapeutic potential. Better in silico-generated starting points for drug-discovery efforts increase the likelihood of success in downstream laboratory-based experimental stages and can contribute to vitally needed reductions in costs and time to market for new therapies. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

9.
Electronics ; 12(9):1977, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2320345

Résumé

Numerical information plays an important role in various fields such as scientific, financial, social, statistics, and news. Most prior studies adopt unsupervised methods by designing complex handcrafted pattern-matching rules to extract numerical information, which can be difficult to scale to the open domain. Other supervised methods require extra time, cost, and knowledge to design, understand, and annotate the training data. To address these limitations, we propose QuantityIE, a novel approach to extracting numerical information as structured representations by exploiting syntactic features of both constituency parsing (CP) and dependency parsing (DP). The extraction results may also serve as distant supervision for zero-shot model training. Our approach outperforms existing methods from two perspectives: (1) the rules are simple yet effective, and (2) the results are more self-contained. We further propose a numerical information retrieval approach based on QuantityIE to answer analytical queries. Experimental results on information extraction and retrieval demonstrate the effectiveness of QuantityIE in extracting numerical information with high fidelity.

10.
Constitutional Political Economy ; 34(2):188-209, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2316789

Résumé

Whether deserved on not, US Presidents often receive the blame or the credit for the nature of the economy and direction of the country. Therefore, the status of the economy and the country in an election year can be a very important factor in election success for an incumbent President (or his party if an incumbent is not running). This is especially true in ‘battleground states' due to the presence of the Electoral College system where Presidential candidates need only win different combinations of states in order to become President. However, the 2020 Presidential election was vastly different from past election cycles in that an additional variable, COVID-19, was added to the decision calculus of voters. Eventually, the 2020 election came down to the extremely slim margins in three states (Arizona, Georgia, and Wisconsin) and thin margins in two others (Pennsylvania and Michigan). This paper shows that deaths from COVID-19 at the county level played a small role in demotivating voters to turnout in 2020 to cast their vote for Joe Biden as President. In other words, without Covid-19, President Trump's losses within these five states would have been even larger.

11.
Strategy & Leadership ; 51(3):27-30, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2316421

Résumé

PurposeWhile strong risk management and contingency planning are important for building capabilities useful for quick adaptation to foreseeable disruptions, they may not be useful for preparing for black swan-type events or situations that lack sufficient precedent to understand how they impact businesses. The key to creating a resilient organization relies most on resilient human capital, who are capable of withering whatever changes Chance may throw at them and the organization.Design/methodology/approachUsing company data and semi-structured interviews, this paper presents the case study of ASK Consulting, a medium-size entrepreneurial enterprise that learned that human resources are the cornerstone of a resilient organization.FindingsResilient people exhibit three common traits: discipline, open-mindedness to change, and a sense of service to the team rather than themselves. Insights about these traits can be elicited by asking prospective employees three questions during their interview.Practical implicationsThis case provides an illustrative case study and straightforward guidance for identifying whether a job candidate has the traits of a resilient person.Originality/valueMuch of the research into organizational resilience focuses on scenario planning, contingencies, and building organizational capabilities. This provides a much more straightforward and actionable approach that focuses on only one type of resource and is not contingent on the availability of slack time and money to implement.

12.
Bioorg Chem ; 138: 106600, 2023 Sep.
Article Dans Anglais | MEDLINE | ID: covidwho-2314909

Résumé

Guanidines are fascinating small nitrogen-rich organic compounds, which have been frequently associated with a wide range of biological activities. This is mainly due to their interesting chemical features. For these reasons, for the past decades, researchers have been synthesizing and evaluating guanidine derivatives. In fact, there are currently on the market several guanidine-bearing drugs. Given the broad panoply of pharmacological activities displayed by guanidine compounds, in this review, we chose to focus on antitumor, antibacterial, antiviral, antifungal, and antiprotozoal activities presented by several natural and synthetic guanidine derivatives, which are undergoing preclinical and clinical studies from January 2010 to January 2023. Moreover, we also present guanidine-containing drugs currently in the market for the treatment of cancer and several infectious diseases. In the preclinical and clinical setting, most of the synthesized and natural guanidine derivatives are being evaluated as antitumor and antibacterial agents. Even though DNA is the most known target of this type of compounds, their cytotoxicity also involves several other different mechanisms, such as interference with bacterial cell membranes, reactive oxygen species (ROS) formation, mitochondrial-mediated apoptosis, mediated-Rac1 inhibition, among others. As for the compounds already used as pharmacological drugs, their main application is in the treatment of different types of cancer, such as breast, lung, prostate, and leukemia. Guanidine-containing drugs are also being used for the treatment of bacterial, antiprotozoal, antiviral infections and, recently, have been proposed for the treatment of COVID-19. To conclude, the guanidine group is a privileged scaffold in drug design. Its remarkable cytotoxic activities, especially in the field of oncology, still make it suitable for a deeper investigation to afford more efficient and target-specific drugs.


Sujets)
Anti-infectieux , Antinéoplasiques , COVID-19 , Tumeurs , Mâle , Humains , Guanidine/pharmacologie , Guanidine/composition chimique , Guanidines/composition chimique , Anti-infectieux/pharmacologie , Antinéoplasiques/pharmacologie , Antinéoplasiques/composition chimique , Antibactériens/pharmacologie , Tumeurs/traitement médicamenteux , Antihypertenseurs , Antiviraux/pharmacologie
13.
Ex Aequo ; - (46):49-68, 2022.
Article Dans Portugais | Scopus | ID: covidwho-2299670

Résumé

The COVID-19 pandemic changed the form and substance of the official campaign for the 2021 Portuguese presidential elections. It called for several adjustments to planned campaign actions, constraining candidates' mobility and popular mobilization. This context favored the fermentation of populist discourses and the radicalization of political debate. These circumstances led to an unprecedented electoral contest in the recent history of democracy in Portugal. One of the least explored topics in studies about populism is gender and the place of women in the globalized society. In this context, this paper examines the media coverage of the 2021 Portuguese presidential elections in television news services of the following channels: RTP1, SIC, TVI and CMTV. This analysis covered the period of the official campaign and focused on the two female candidates, Ana Gomes and Marisa Matias. © 2022 Associacao Portuguesa de Estudos sobre as Mulheres. All rights reserved.

14.
International Journal of Education & Literacy Studies ; 11(2):64-69, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2294746

Résumé

The purpose of this research is to investigate the attitudes of Turkish teacher candidates towards distance Turkish teaching in terms of gender, owning a personal computer, previous experience of taking distance education lessons before the COVID-19 pandemic, and daily internet usage. The relational survey model was used. The study group consisted of 133 Turkish teacher candidates (77 women and 56 men) studying at Department of Turkish Education, Dede Korkut Education Faculty, Kafkas University 2021-2022 Spring Semester. Research data was collected through Google Docs. Independent samples t-test and One-Way Analysis of Variance (ANOVA) were used to analyze the data. As a result of the research, it was found that the attitudes of Turkish teacher candidates towards distance Turkish teaching did not differ significantly in terms of gender, but it was found that there was a difference in favor of women in the technology dimension. While there was no significant difference between the attitudes of the teacher candidates who owned a PC and those who did not. It was also found that there was an important difference in the optimism dimension. It was found that there was no significant difference in terms of whether or not they took distance education lessons before the COVID-19 pandemic and daily internet usage.

15.
Studies in Graduate and Postdoctoral Education ; 14(2):134-150, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2277164

Résumé

PurposeThe COVID-19 pandemic has had its impact on research and researchers, potentially influencing the future of academia. Yet, to the best of the authors' knowledge, there are no empirical studies on the alignment between supervisors' and supervisees' estimates of the impact of COVID-19. This study aims to contribute to bridging this gap by exploring PhD candidates' and supervisors' perceptions of the impact of COVID-19 on candidates' study progress and study well-being, and whether the estimates were related to supervisors' and supervisees' well-being.Design/methodology/approachA total of 768 PhD candidates and 561 doctoral supervisors from a large multifield research-intensive university in Finland participated in this quantitative study. Data were collected with the doctoral experience survey and the supervisory experience survey.FindingsIn general, the results show that both supervisors and supervisees recognised the negative impact of the pandemic on candidates' well-being and progress, and their perceptions were quite well aligned. However, supervisors estimated that the impact had been more detrimental than the supervisees did. The results also show that the supervisors' perceptions of the negative impact of COVID-19 on candidates' progress and well-being were related to reduced levels of their own well-being.Originality/valueResults can be used in developing effective support means for both the supervisors and supervisees to overcome the hardships caused by the COVID-19 pandemic and to avoid long-term negative consequences for the candidates in degree completion, career trajectories and the future of the academy.

16.
Government and Opposition ; 58(2):249-267, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2267754

Résumé

How do right-wing-populist incumbents navigate rhetorical strategic choices when they seek to manage external crises? Relevant literature has paid increasing attention to the role of ‘crisis' in boosting the electoral success of right-wing populist candidates. We know a lot less about the rhetorical strategies used by right-wing populist incumbents seeking re-election. We draw on literatures on populism, crisis management and political rhetoric to conceptualize the rhetorical strategic choices of right-wing populist incumbents in times of crisis. We propose a framework for the choice of rhetorical strategy available to right-wing populist incumbents and illustrate it with a qualitative content analysis of Trump's tweets and White House press briefings during the first months of the COVID-19 pandemic. We find limited rhetorical adaptation to crisis and high degrees of continuity with previous rhetoric grounded in right-wing populism. This challenges prevalent assumptions regarding the likelihood of incumbent rhetorical flexibility in the face of crisis.

17.
Journal of Policy Analysis and Management ; 42(2):525-551, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2251842

Résumé

Master's degree enrollment and debt have increased substantially in recent years, raising important questions about the labor market value of these credentials. Using a field experiment featuring 9,480 job applications submitted during the early months of the COVID‐19 pandemic, I examine employers' responses to job candidates with a Master of Business Administration (MBA), which represents one‐quarter of all master's degrees in the United States. I focus on MBAs from three types of less‐selective institutions that collectively enroll the vast majority of master's students: for‐profit, online, and regional universities. Despite the substantial time and expense required for these degrees, job candidates with MBAs from all three types of institutions received positive responses from employers at the same rate as candidates who only had a bachelor's degree—even for positions that listed a preference for a master's degree. Additionally, applicants with names suggesting they were Black men received 30 percent fewer positive responses than otherwise equivalent applicants whose names suggested they were White men or women, providing further evidence of racial discrimination in hiring practices.

18.
The Canadian Music Educator ; 64(3):47-48, 2023.
Article Dans Anglais | ProQuest Central | ID: covidwho-2249900

Résumé

During my time with the NLMEA we worked to provide quality professional development across the province, advocate for music education in schools as well as at the university level and helped navigate and advocate for music education during the Covid-19 pandemic. In addition to the BCMEA, I also serve on the boards of other volunteer organizations such as the Island Ukuleles Music Society and have been asked to fulfill a role that is opening on the board of the Victoria Jazz Society (due to my status as a professional trumpet player in Greater Victoria). With all of this experience, I feel that I am a strong candidate for the position of Director of Public Relations/Member Engagement for the Canadian Music Educators' Association Elected Board.

19.
2nd IEEE International Conference on Mobile Networks and Wireless Communications, ICMNWC 2022 ; 2022.
Article Dans Anglais | Scopus | ID: covidwho-2288234

Résumé

An examination is an essential aspect of learning. The traditional method of examination is when the exam taker takes an assessment in a room or a huge space with other candidates while being supervised by the exam monitor. Although the term 'Online Examination' has existed for a while, however, it has been taking off recently due to the global nation closing as a precautionary measure to prevent the spreading of the Covid-19 virus. Many institutions have their way of conducting online examinations, which prompt many responses from the exam takers. While it is undeniable that online examination could increase efficiency in conducting an examination, multiple factors could influence the success of conducting a smooth online examination. Hence, this paper will study exam taker's sentiments towards online examinations based on the current online exam implementation in their institutions. A questionnaire survey was conducted throughout 67 exam takers above the age of 18, where their responses are gathered and analyzed in identifying their concerns and obstacles when taking an online examination. The results would be helpful for institutions to formulate a method for creating an online examination method that would be both efficient and convenient for both students, lecturers, and staff of the institution. © 2022 IEEE.

20.
Cureus ; 15(2): e34927, 2023 Feb.
Article Dans Anglais | MEDLINE | ID: covidwho-2283993

Résumé

BACKGROUND: The residency interview is a crucial step that helps the program identify potential new trainees while the trainees find out more about the program. With the onset of the COVID-19 pandemic, it became essential to hold interviews virtually. OBJECTIVE: Here, we conducted a questionnaire-based study to identify areas of improvement in the virtual interview process in our program. METHODS: The study was conducted among the residency interview applicants of the 2022 match cycle. A questionnaire was sent via email to all applicants who were invited to our residency program for an interview. Out of the 600 applicants who were interviewed in our program, 230 applicants answered the survey, an 11-point questionnaire pertaining to the various aspects of the interview process. RESULTS:  A virtual interview with an option of in-person is the most favored answer among the different groups, i.e., American Medical Graduates (AMGs), International Medical Graduates (IMGs) without need for a visa, and IMGs with a need for a visa, respectively, were, 37.5%, 42.8%, and 38.65%, respectively. An updated website with all required information was a top resource used by 95%, 84.5%, and 89.6% of the different groups of candidates. American medical graduates (32.50%) place high importance on resident interaction, while international medical graduates want the programs to focus on their website and provide more information about all aspects of the program during the virtual interview. CONCLUSIONS: In the post-COVID-19 era, Internal Medicine programs will need to improve several aspects of virtual interviews while assessing what is important to candidates.

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